Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387224 | 0.90 | ALDH1A1 (0.36) | GSK3BTSHRSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL4387999 | 0.89 | GSK3B (0.37) | GSK3BRAB9ANPC1HPGDTSHR | |
| SCHEMBL4384554 | 0.79 | GSK3B (0.37) | GSK3BTSHRALDH1A1CYP3A4 | |
| SCHEMBL4381292 | 0.77 | GSK3B (0.41) | GSK3BRAB9ANPC1CYP3A4 | |
| SCHEMBL4387202 | 0.76 | GSK3B (0.41) | GSK3BRAB9ANPC1CYP3A4 | |
| SCHEMBL4378591 | 0.76 | GSK3B (0.38) | GSK3BCYP3A4 | |
| SCHEMBL3373754 | 0.72 | OPRD1 (0.41) | GSK3BRAB9ANPC1CYP3A4 | |
| SCHEMBL2066100 | 0.72 | GSK3B (0.43) | GSK3BALDH1A1CYP3A4 | |
| SCHEMBL2065915 | 0.72 | GSK3B (0.37) | GSK3B | |
| SCHEMBL3659041 | 0.72 | GSK3B (0.45) | GSK3BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |