Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.50 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4544205 | 0.96 | CYP1A2 (0.64) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL4396731 | 0.96 | CYP1A2 (0.64) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1088580 | 0.96 | CYP1A2 (0.69) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15692161 | 0.87 | MAPK1 (0.56) | CYP1A2BACE1TDP1KDM4EPOLB | |
| SCHEMBL670646 | 0.86 | CYP1A2 (0.62) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL951744 | 0.86 | MAPT (0.65) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30946935 | 0.84 | ALDH1A1 (0.63) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30388558 | 0.84 | ALDH1A1 (0.63) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17600557 | 0.84 | ALDH1A1 (0.63) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6859623 | 0.84 | ALDH1A1 (0.63) | CYP1A2BACE1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629431-B2 | Polycarbonate prepolymer for solid phase polymerization and process for producing polycarbonate | IDEMITSU KOSAN CO., LTD. (JP) | 2009-12-08 | — | — | US | disclosed |
| US-20080064847-A1 | Oxidative carbonylation; molecular weight control | IDEMISU KOSAN CO., LTD. (JP) | 2008-03-13 | — | — | US | disclosed |