Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3010526 | 0.99 | FAAH (0.49) | FAAHTHRBMAPTMEN1KMT2A | |
| SCHEMBL3006058 | 0.94 | THRB (0.45) | FAAHTHRBMAPTMEN1KMT2A | |
| SCHEMBL2994451 | 0.93 | FAAH (0.48) | FAAHTHRBMAPTMEN1KMT2A | |
| SCHEMBL4384405 | 0.92 | FAAH (0.51) | FAAHMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4097912 | 0.91 | FAAH (0.51) | FAAHMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3007578 | 0.90 | FAAH (0.51) | FAAHMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3007962 | 0.89 | L3MBTL1 (0.45) | FAAHTHRBMAPTMEN1KMT2A | |
| SCHEMBL2170308 | 0.89 | FAAH (0.61) | FAAHTHRBMAPTMEN1KMT2A | |
| SCHEMBL3006454 | 0.88 | FAAH (0.48) | FAAHTHRBMAPTMEN1KMT2A | |
| SCHEMBL4096099 | 0.88 | FAAH (0.46) | FAAHTHRBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |