Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 5/20 | 0.44 |
| ▸ | METAP1 | P53582 | 5/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371317 | 0.84 | ALDH1A1 (0.48) | ALDH1A1METAP2METAP1LMNAGAA | |
| SCHEMBL4384637 | 0.77 | POLB (0.39) | ALDH1A1LMNA | |
| SCHEMBL4380601 | 0.77 | SLC6A4 (0.47) | ALDH1A1LMNACYP2C9 | |
| SCHEMBL8518963 | 0.75 | LMNA (0.61) | METAP2METAP1SSTR4LMNAGAA | |
| SCHEMBL2934798 | 0.75 | LMNA (0.61) | METAP2METAP1SSTR4LMNAGAA | |
| SCHEMBL7263715 | 0.75 | LMNA (0.61) | METAP2METAP1SSTR4LMNAGAA | |
| SCHEMBL9950214 | 0.74 | ALDH1A1 (0.62) | ALDH1A1CYP2C9 | |
| SCHEMBL9950211 | 0.74 | ALDH1A1 (0.62) | ALDH1A1CYP2C9 | |
| SCHEMBL30861790 | 0.74 | ALDH1A1 (0.62) | ALDH1A1CYP2C9 | |
| SCHEMBL19514728 | 0.74 | ALDH1A1 (0.62) | ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-2114388-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008098105-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |