Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833715 | 0.86 | ITGB3 (0.47) | ITGB3ITGA2BKMT2AHPSEF2 | |
| SCHEMBL2838666 | 0.82 | KMT2A (0.48) | ITGB3ITGA2BKMT2APOLBPLAU | |
| SCHEMBL2836334 | 0.82 | ITGB3 (0.52) | ITGB3ITGA2BKMT2APOLBMEN1 | |
| SCHEMBL4235103 | 0.81 | ALDH1A1 (0.46) | ITGB3KCNK9KCNK3KMT2APOLB | |
| SCHEMBL2833035 | 0.79 | ITGB3 (0.48) | ITGB3ITGA2BKCNK9KCNK3KMT2A | |
| SCHEMBL7455765 | 0.78 | ITGB3 (0.58) | ITGB3ITGA2BKCNK9KCNK3KMT2A | |
| SCHEMBL2838002 | 0.78 | MAPK1 (0.52) | ITGB3ITGA2BKMT2AF2PLG | |
| SCHEMBL2842084 | 0.78 | KMT2A (0.45) | ITGB3ITGA2BKCNK9KCNK3KMT2A | |
| SCHEMBL2836327 | 0.78 | ITGB3 (0.43) | ITGB3ITGA2BKMT2AMEN1 | |
| SCHEMBL2836989 | 0.77 | ITGB3 (0.50) | ITGB3ITGA2BKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |