Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985136 | 0.95 | ALDH1A1 (0.60) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| SCHEMBL1135597 | 0.95 | ALDH1A1 (0.60) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| Nitrous Acid SCHEMBL1613758 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| Nitrous Acid SCHEMBL6927483 | 0.92 | ALDH1A1 (0.53) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| SCHEMBL28375108 | 0.79 | CYP3A4 (0.50) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| SCHEMBL23499978 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| SCHEMBL28058443 | 0.77 | CASP6 (0.66) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| SCHEMBL589016 | 0.77 | CASP6 (0.66) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| SCHEMBL3065809 | 0.75 | CASP6 (0.59) | ALDH1A1HPRT1CASP6CTSBTDP1 | |
| Nitric Acid SCHEMBL31633545 | 0.75 | ALDH1A1 (0.44) | ALDH1A1HPRT1CASP6TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605176-B1 | Lubricated and sealed rolling bearing | JTEKT CORP (JP) | 2008-09-03 | — | — | EP | claimed |
| EP-1089003-B1 | Lubricated and sealed rolling bearing | KOYO SEIKO CO (JP) | 2005-12-28 | — | — | EP | claimed |
| EP-1605176-A1 | Lubricated and sealed rolling bearing | Koyo Seiko Co., Ltd. (JP) | 2005-12-14 | — | — | EP | claimed |
| EP-1089003-A1 | Lubricated and sealed rolling bearing | Koyo Seiko Co., Ltd. (JP) | 2001-04-04 | — | — | EP | claimed |
| EP-1591683-B1 | Rolling bearing | JTEKT CORP (JP) | 2009-12-02 | — | — | EP | disclosed |
| EP-1605176-B1 | Lubricated and sealed rolling bearing | JTEKT CORP (JP) | 2008-09-03 | — | — | EP | disclosed |
| EP-1089003-B1 | Lubricated and sealed rolling bearing | KOYO SEIKO CO (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-1605176-A1 | Lubricated and sealed rolling bearing | Koyo Seiko Co., Ltd. (JP) | 2005-12-14 | — | — | EP | disclosed |
| EP-1591683-A2 | Rolling bearing | Koyo Seiko Co., Ltd. (JP) | 2005-11-02 | — | — | EP | disclosed |
| EP-1089003-A1 | Lubricated and sealed rolling bearing | Koyo Seiko Co., Ltd. (JP) | 2001-04-04 | — | — | EP | disclosed |