Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.52 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132486 | 0.85 | ALDH1A1 (0.56) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| SCHEMBL19410088 | 0.85 | ALDH1A1 (0.56) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| SCHEMBL28118098 | 0.85 | ALDH1A1 (0.58) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| SCHEMBL30548844 | 0.84 | ALDH1A1 (0.52) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| SCHEMBL18293369 | 0.84 | ALDH1A1 (0.52) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| SCHEMBL30548843 | 0.84 | ALDH1A1 (0.52) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| Nicotine SCHEMBL11351392 | 0.84 | ALDH1A1 (0.77) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| (+/-)Nicotine SCHEMBL11351399 | 0.84 | ALDH1A1 (0.77) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| (+/-)Nicotine SCHEMBL29482411 | 0.84 | ALDH1A1 (0.77) | KDM4EBLMALOX15ALDH1A1TDP1 | |
| SCHEMBL18293370 | 0.83 | ALDH1A1 (0.51) | KDM4EBLMALOX15ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994443-B2 | Modified nicotinic compounds and related methods | SELECTA BIOSCIENCES, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994443-B2 | Modified nicotinic compounds and related methods | SELECTA BIOSCIENCES, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| WO-2012061717-A1 | MODIFIED NICOTINIC COMPOUNDS AND RELATED METHODS | SELECTA BIOSCIENCES, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20120114677-A1 | MODIFIED NICOTINIC COMPOUNDS AND RELATED METHODS | SELECTA BIOSCIENCES, INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120114677-A1 | MODIFIED NICOTINIC COMPOUNDS AND RELATED METHODS | SELECTA BIOSCIENCES, INC. (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114677-A1 | MODIFIED NICOTINIC COMPOUNDS AND RELATED METHODS | NNMT, CHRNG, CHRM5 | KDM4E 866/4885BLM 3442/4885ALOX15 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.