Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29376674 | 0.81 | IDO1 (0.50) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL189955 | 0.81 | IDO1 (0.50) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL2619219 | 0.72 | IDO1 (0.43) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL13996329 | 0.71 | IDO1 (0.47) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL27077818 | 0.67 | ALDH1A1 (0.41) | JAK2IDO1ALDH1A1 | |
| SCHEMBL1077138 | 0.65 | NOS1 (0.55) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL21894631 | 0.65 | JAK2 (1.00) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL28808758 | 0.65 | JAK2 (0.54) | JAK2JAK1IDO1NOS1AXL | |
| SCHEMBL17160219 | 0.64 | JAK2 (0.41) | JAK2JAK1IDO1METAP2RAF1 | |
| SCHEMBL20789987 | 0.62 | NOS1 (0.55) | JAK2JAK1IDO1NOS1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |