Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.76 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.76 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11939894 | 1.00 | GABRA1 (0.76) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL5090886 | 1.00 | GABRA1 (0.76) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL4390789 | 0.91 | GABRA1 (0.77) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL28853680 | 0.91 | GABRA1 (0.77) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| Propoxate SCHEMBL1817957 | 0.89 | GABRA1 (0.81) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL12786511 | 0.88 | GABRA1 (0.76) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| Propoxate SCHEMBL10695613 | 0.88 | GABRA1 (0.80) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL22755916 | 0.88 | GABRA1 (0.76) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL22696745 | 0.88 | GABRA1 (0.76) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 | |
| SCHEMBL18202377 | 0.88 | GABRA1 (0.76) | GABRA1GABRB2CYP1A2CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071785-B2 | Synthesis and evaluation of 18F-labelled-alkyl-1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands | GE HEALTHCARE LIMITED (GB) | 2011-12-06 | — | — | US | disclosed |
| US-20090297447-A1 | SYNTHESIS AND EVALUATION OF 18F-LABELLED-ALKYL-1-[(1R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF BETA-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS | LANGSTROM BENGT | 2009-12-03 | — | — | US | disclosed |
| US-20080206138-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | Zolle, Ilse (AT) | 2008-08-28 | — | — | US | disclosed |
| US-20080206138-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | Zolle, Ilse (AT) | 2008-08-28 | — | — | US | disclosed |
| US-20080207916-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | Zolle, Ilse (AT) | 2008-08-28 | — | — | US | disclosed |
| US-20080207916-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | Zolle, Ilse (AT) | 2008-08-28 | — | — | US | disclosed |
| US-20080207916-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | Zolle, Ilse (AT) | 2008-08-28 | — | — | US | disclosed |
| US-20080206138-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | Zolle, Ilse (AT) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090297447-A1 | SYNTHESIS AND EVALUATION OF 18F-LABELLED-ALKYL-1-[(1R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF BETA-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS | HSD11B1, CYP21A2, CYP11B1 | GABRA1 828/4885GABRB2 1953/4885CYP1A2 124/4885 |
| US-20080206138-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | CYP11B1, CYP21A2, CYP17A1 | GABRA1 264/4885GABRB2 947/4885CYP1A2 43/4885 |
| US-20080207916-A1 | Radiolabelled Phenylethyl Imidazole Carboxylic Acid Ester Derivatives | PAICS, PIGO, GRPR | GABRA1 166/4885GABRB2 791/4885CYP1A2 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.