Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.51 |
| ▸ | ACE | P12821 | 3/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | GLI1 | P08151 | 2/20 | 0.44 |
| ▸ | GLI2 | P10070 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147315 | 0.87 | MME (0.51) | MMEACEERCC1ERCC4GLI1 | |
| SCHEMBL6137585 | 0.85 | MME (0.62) | MMEACEERCC1ERCC4ALDH1A1 | |
| SCHEMBL3143059 | 0.82 | GLI1 (0.65) | GLI1GLI2CA12CA1CA2 | |
| SCHEMBL27598564 | 0.81 | PTGS1 (0.65) | MMEACEERCC1ERCC4GLI1 | |
| SCHEMBL1891876 | 0.81 | PTGS1 (0.65) | MMEACEERCC1ERCC4GLI1 | |
| SCHEMBL17889085 | 0.80 | CXCL8 (0.52) | GLI1GLI2CA12CA1CA2 | |
| SCHEMBL4386602 | 0.79 | MME (0.47) | MMEACEERCC1ERCC4GLI1 | |
| 2-{3-[Hydroxy(Phenyl)Methyl]Phenyl}Propanoic Acid SCHEMBL8851028 | 0.78 | PTGS1 (0.62) | ALDH1A1MEN1MAPTKMT2AHPGD | |
| 2-{3-[Hydroxy(Phenyl)Methyl]Phenyl}Propanoic Acid SCHEMBL12129512 | 0.78 | PTGS1 (0.62) | ALDH1A1MEN1MAPTKMT2AHPGD | |
| 2-{3-[Hydroxy(Phenyl)Methyl]Phenyl}Propanoic Acid SCHEMBL4380095 | 0.78 | PTGS1 (0.62) | ALDH1A1MEN1MAPTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255726-B1 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-11-11 | — | — | EP | disclosed |
| US-20040181073-A1 | Amides, useful in the inhibition of il-8-induced chemotaxis of neutrophils | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181073-A1 | Amides, useful in the inhibition of il-8-induced chemotaxis of neutrophils | CXCL8, MMP8, CCR8 | MME 2941/4885ACE 1844/4885ERCC1 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.