Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.51 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 8/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.51 |
| ▸ | HRH1 | P35367 | 8/20 | 0.51 |
| ▸ | DRD3 | P35462 | 8/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.51 |
| ▸ | HTR6 | P50406 | 7/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.51 |
| ▸ | HRH2 | P25021 | 6/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 6/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.51 |
| ▸ | DRD5 | P21918 | 5/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.51 |
| ▸ | HTR7 | P34969 | 5/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13588936 | 0.94 | SLC6A3 (0.47) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| Oxalic Acid SCHEMBL4380546 | 0.85 | SLC6A3 (0.54) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| Oxalic Acid SCHEMBL4391692 | 0.84 | SLC6A3 (0.57) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| SCHEMBL8225045 | 0.79 | SLC6A3 (0.51) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| Oxalic Acid SCHEMBL4382481 | 0.79 | DRD3 (0.49) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| SCHEMBL13588937 | 0.77 | SLC6A3 (0.54) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| Oxalic Acid SCHEMBL4380272 | 0.77 | HTR2A (0.48) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| Oxalic Acid SCHEMBL4395310 | 0.77 | TACR1 (0.46) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| SCHEMBL7295696 | 0.75 | SCN5A (0.58) | HTR2AADRA1AHRH1DRD3SLC6A3 | |
| SCHEMBL4752728 | 0.74 | CACNA1F (0.67) | HTR2AADRA1AHRH1DRD3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298878-A1 | OXIME COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298878-A1 | OXIME COMPOUNDS AND THE USE THEREOF | KCNN4, CACNA1A, KCNN3 | OPRM1 55/4885SLC6A4 446/4885HTR2A 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.