Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.40 |
| ▸ | EDNRB | P24530 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099175 | 0.97 | ALOX5AP (0.38) | PLA2G2AEDNRBFAAHF2RL3ALOX5AP | |
| SCHEMBL4095857 | 0.96 | PLA2G2A (0.42) | PLA2G2AFAAHF2RL3PTGS2ALOX5AP | |
| SCHEMBL3002874 | 0.90 | PTGS2 (0.46) | PLA2G2AEDNRBFAAHPTGS2LMNA | |
| SCHEMBL3008455 | 0.89 | MEN1 (0.42) | PLA2G2AEDNRBFAAHLMNASMN1; SMN2 | |
| SCHEMBL3007424 | 0.89 | NPC1 (0.38) | PLA2G2AEDNRBFAAHF2RL3ALOX5AP | |
| SCHEMBL4088892 | 0.88 | EPHX2 (0.40) | FAAHLMNASMN1; SMN2 | |
| SCHEMBL3001872 | 0.88 | PLA2G2A (0.41) | PLA2G2AFAAHF2RL3PTGS2PTGDR2 | |
| SCHEMBL4088383 | 0.88 | FAAH (0.46) | FAAHALOX5AP | |
| SCHEMBL3005046 | 0.87 | FAAH (0.41) | FAAHF2RL3ALOX5APLMNASMN1; SMN2 | |
| SCHEMBL3008903 | 0.87 | MEN1 (0.41) | EDNRBF2RL3ALOX5APLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |