SCHEMBL4386993

SCHEMBL4386993

CCC(OC(C)=O)c1ccc(F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.46
ALDH1A1 P00352 2/20 0.41
LMNA P02545 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
ALPG P10696 1/20 0.41
AOC3 Q16853 1/20 0.40
CYP19A1 P11511 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
PABPC1 P11940 1/20 0.39
APOBEC3A P31941 1/20 0.39
APOBEC3G Q9HC16 1/20 0.39
HPGD P15428 1/20 0.39
KLK7 P49862 1/20 0.39
FAAH O00519 1/20 0.39
MMP1 P03956 1/20 0.38
MMP3 P08254 1/20 0.38
CYP2D6 P10635 1/20 0.38
MMP9 P14780 1/20 0.38
MMP12 P39900 1/20 0.38
KCNH2 Q12809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14547167 1.00 SIGMAR1 (0.46) SIGMAR1ALDH1A1LMNASMN1; SMN2ALPG
SCHEMBL1788624 0.87 ALDH1A1 (0.42) ALDH1A1LMNASMN1; SMN2ALPGAOC3
SCHEMBL6189452 0.84 SIGMAR1 (0.45) SIGMAR1ALDH1A1AOC3CYP19A1PABPC1
SCHEMBL14028741 0.84 ESR1 (0.48) ALDH1A1LMNATDP1PABPC1APOBEC3A
SCHEMBL20622236 0.83 SIGMAR1 (0.44) SIGMAR1ALDH1A1AOC3CYP19A1TDP1
SCHEMBL9608808 0.81 PABPC1 (0.55) ALDH1A1LMNAPABPC1APOBEC3AAPOBEC3G
SCHEMBL664962 0.81 PABPC1 (0.55) ALDH1A1LMNAPABPC1APOBEC3AAPOBEC3G
SCHEMBL2294116 0.81 PABPC1 (0.55) ALDH1A1LMNAPABPC1APOBEC3AAPOBEC3G
SCHEMBL867225 0.81 FFAR1 (0.45)
SCHEMBL7647810 0.81 SIGMAR1 (0.44) SIGMAR1ALDH1A1SMN1; SMN2AOC3CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2124549-A1 ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS Merck & Co., Inc. (US) 2009-12-02 EP disclosed
WO-2008085300-A1 ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS MERCK & CO., INC. (US) 2008-07-17 WO disclosed