Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | PKM | P14618 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4389601 | 0.77 | ALDH1A1 (0.38) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4394084 | 0.74 | L3MBTL1 (0.39) | MAPTALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL4381914 | 0.73 | POLB (0.45) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4385682 | 0.72 | ALDH1A1 (0.37) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4387053 | 0.71 | MAPT (0.36) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4379804 | 0.70 | PDE4B (0.41) | MAPTESR2NPSR1CYP2C19KMT2A | |
| SCHEMBL4383921 | 0.70 | ALDH1A1 (0.42) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4387564 | 0.67 | ALDH1A1 (0.35) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4387566 | 0.67 | ALDH1A1 (0.35) | MAPTALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL4392414 | 0.67 | ALDH1A1 (0.35) | MAPTALDH1A1KDM4EPKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| EP-1704856-A1 | HSP90 FAMILY PROTEIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | MAPT 2443/4885ALDH1A1 3520/4885KDM4E 3223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.