Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27511461 | 0.89 | SLC2A1 (0.48) | TOP2ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| Methyl Phosphonate SCHEMBL4397039 | 0.86 | KCNH3 (0.41) | TOP2APOLBRAD52HTT | |
| SCHEMBL27511792 | 0.83 | SLC2A1 (0.53) | SLC2A1POLBRAD52ELANERAB9A | |
| SCHEMBL28744827 | 0.83 | SLC2A1 (0.53) | SLC2A1POLBRAD52ELANERAB9A | |
| SCHEMBL27804260 | 0.82 | TOP2A (0.43) | TOP2ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8851369 | 0.79 | IDO1 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19SLC2A1 | |
| Methyl Phosphonate SCHEMBL4381295 | 0.78 | KMT2A (0.53) | HDAC1POLBRAD52 | |
| SCHEMBL10362358 | 0.77 | POLB (0.49) | SLC2A1POLBRAD52RAB9ATSHR | |
| SCHEMBL27911498 | 0.76 | POLB (0.45) | SLC2A1POLBRAD52RAB9ATSHR | |
| SCHEMBL10691567 | 0.74 | G6PD (0.48) | CYP1A2CYP2C9CYP2C19POLBCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101730565-B | Substituted phosphonates and their use for reducing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE | 2015-06-10 | — | — | CN | disclosed |
| US-7629379-B2 | Substituted phosphonate fluorescent sensors and use thereof | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2009-12-08 | — | — | US | disclosed |
| US-20070049761-A1 | Substituted phosphonate fluorescent sensors and use thereof | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2007-03-01 | — | — | US | disclosed |
| EP-1625134-A2 | SUBSTITUTED PHOSPHONATE FLUORESCENT SENSORS AND USE THEREOF | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004101579-A2 | SUBSTITUTED PHOSPHONATE FLUORESCENT SENSORS AND USE THEREOF | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049761-A1 | Substituted phosphonate fluorescent sensors and use thereof | NR2E3, CASR, NR3C2 | TOP2A 2467/4885HDAC3 989/4885HDAC1 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.