Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.47 |
| ▸ | CCND1 | P24385 | 17/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391454 | 0.94 | SMN1; SMN2 (0.45) | CDK4CCND1 | |
| SCHEMBL4397673 | 0.93 | SMN1; SMN2 (0.44) | CDK4CCND1 | |
| SCHEMBL4391535 | 0.89 | CDK4 (0.51) | CDK4CCND1CDK2 | |
| SCHEMBL4386318 | 0.89 | CDK4 (0.48) | CDK4CCND1CDK2 | |
| SCHEMBL4397592 | 0.88 | IDO1 (0.51) | CDK4CCND1 | |
| SCHEMBL4389016 | 0.88 | IDO1 (0.50) | CDK4CCND1 | |
| SCHEMBL4381230 | 0.88 | CDK4 (0.43) | CDK4CCND1 | |
| SCHEMBL4388022 | 0.87 | CDK4 (0.49) | CDK4CCND1 | |
| SCHEMBL4393858 | 0.85 | CDK4 (0.43) | CDK4CCND1 | |
| SCHEMBL4388625 | 0.85 | HTR2A (0.45) | CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893575-B1 | 2-(1H-INDOLYLSULFANYL)-ARYL AMINE DERIVATIVES | H LUNDBECK AS (DK) | 2017-01-11 | — | — | EP | disclosed |
| US-7629473-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2009-12-08 | — | — | US | disclosed |
| EP-1893575-A2 | 2-(1H-INDOLYLSULFANYL)-ARYL AMINE DERIVATIVES | H.Lundbeck A/S (DK) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134499-A2 | 2-(1H-INDOLYLSULFANYL)-ARYL AMINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-12-21 | — | — | WO | disclosed |
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | CYP11B2, CYP1A2, CYP4B1 | CDK4 550/4885CCND1 686/4885CDK2 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.