Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.49 |
| ▸ | CCND1 | P24385 | 12/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384406 | 0.88 | IDO1 (0.41) | CDK4CCND1TUBB4ATUBBTUBA3C | |
| SCHEMBL4387834 | 0.87 | CDK4 (0.47) | CDK4CCND1 | |
| SCHEMBL4391535 | 0.87 | CDK4 (0.51) | CDK4CCND1IDO1 | |
| SCHEMBL4396269 | 0.86 | IDO1 (0.45) | CDK4CCND1MAPTMEN1CYP1A2 | |
| SCHEMBL4386318 | 0.85 | CDK4 (0.48) | CDK4CCND1TUBB4ATUBBTUBA3C | |
| SCHEMBL4391454 | 0.84 | SMN1; SMN2 (0.45) | CDK4CCND1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4388970 | 0.82 | HTR6 (0.47) | CDK4CCND1TACR1 | |
| SCHEMBL4397673 | 0.81 | SMN1; SMN2 (0.44) | CDK4CCND1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4397756 | 0.79 | ACHE (0.42) | CDK4CCND1IDO1 | |
| SCHEMBL4388802 | 0.79 | HTR6 (0.43) | CDK4CCND1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629473-B2 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2009-12-08 | — | — | US | disclosed |
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | H. LUNDBECK A/S (DK) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287382-A1 | 2-(1H-indolylsulfanyl)-aryl amine derivatives | CYP11B2, CYP1A2, CYP4B1 | CDK4 550/4885CCND1 686/4885TUBB4A 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.