Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.41 |
| ▸ | CCR4 | P51679 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230866 | 0.76 | PIK3CA (0.47) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL5093415 | 0.75 | PIK3CA (0.55) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL13588449 | 0.75 | PIK3CA (0.47) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL4380274 | 0.74 | PIK3CA (0.53) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL13588448 | 0.73 | PIK3CA (0.52) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL4385243 | 0.70 | JAK2 (0.63) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL4387875 | 0.68 | PIK3CA (0.46) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL443407 | 0.68 | MAPT (0.60) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL8239154 | 0.67 | L3MBTL1 (0.46) | PIK3CGPIK3CAPIK3CBMAPTMEN1 | |
| SCHEMBL4583186 | 0.66 | PIK3CA (0.44) | PIK3CGPIK3CAPIK3CBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |