⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329689 | 0.97 | — | — | |
| SCHEMBL194338 | 0.73 | — | — | |
| SCHEMBL4911003 | 0.72 | — | — | |
| SCHEMBL2499397 | 0.72 | FDPS (0.33) | — | |
| SCHEMBL24233286 | 0.72 | SMN1; SMN2 (0.40) | — | |
| SCHEMBL24496310 | 0.72 | CHRNA7 (0.42) | — | |
| SCHEMBL57304 | 0.72 | — | — | |
| SCHEMBL382220 | 0.71 | — | — | |
| SCHEMBL840412 | 0.69 | CHRNA7 (0.41) | — | |
| SCHEMBL24435951 | 0.69 | CHRNA7 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193394-B2 | Process for production of lasofoxifene or analogue thereof | TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20090012314-A1 | Process for Production of Lasofoxifene or Analogue Thereof | TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1982981-A1 | PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF | Tokyo University of Science, Educational Foundation (JP) | 2008-10-22 | — | — | EP | disclosed |
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |