SCHEMBL4388491

SCHEMBL4388491

CCC(C)c1ccccc1N(c1ccc(Br)cc1)c1ccc(Br)cc1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.46
RAB9A P51151 1/20 0.33
ATM Q13315 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
HTT P42858 1/20 0.33
PTPN2 P17706 1/20 0.32
PTPN1 P18031 1/20 0.32
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
KDM4E B2RXH2 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
CYP1A2 P05177 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5809269 0.86 TSHR (0.52) TSHRATMNISCHHTTKDM4E
SCHEMBL8531953 0.83 TSHR (0.46) TSHRRAB9AATMNISCHKDM4E
SCHEMBL4911533 0.80 TSHR (0.42) TSHRRAB9AATMNISCHHTT
SCHEMBL7572744 0.80 TSHR (0.42) TSHRATMNISCHHTT
SCHEMBL5187335 0.80 TSHR (0.42) TSHRATMNISCHHTT
SCHEMBL5223350 0.74 TSHR (0.55) TSHRATMNISCHKDM4EL3MBTL1
SCHEMBL134479 0.73 CYP2C9 (0.42) TSHR
SCHEMBL1954222 0.72 ALDH1A1 (0.46) TSHRRAB9AATMHTTCES2
SCHEMBL1957205 0.72 ALDH1A1 (0.46) TSHRRAB9AATMHTTCES2
SCHEMBL3123215 0.71 TSHR (0.47) TSHRATMNISCHHTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7632908-B2 Substituted fluorene polymers, their preparation and use in optical devices CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2009-12-15 US disclosed
US-7629429-B2 Aromatic resin; optical device; overcoating substrate with polymer; charge transfer compound, charge generating compoind CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2009-12-08 US disclosed
US-20060223208-A1 Optical device CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2006-10-05 US disclosed
EP-1586617-A1 Substituted fluorene polymers, their preparations and use in optical devices Cambridge Display Technology Limited (GB) 2005-10-19 EP disclosed
EP-1385918-B1 SUBSTITUTED FLUORENE POLYMERS, THEIR PREPARATION AND USE IN OPTICAL DEVICES CAMBRIDGE DISPLAY TECH LTD (GB) 2005-04-06 EP disclosed
US-20040170839-A1 Substituted fluorenes polymers, their preparation and use in optical devices CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-09-02 US disclosed
US-20040158017-A1 Substituted fluorene polymers their preparation and uses CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-08-12 US disclosed
EP-1385919-B1 SUBSTITUTED FLUORENE POLYMERS, THEIR PREPARATION AND USES CAMBRIDGE DISPLAY TECH LTD (GB) 2004-08-11 EP disclosed
WO-2004034749-A1 OPTICAL DEVICE CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-04-22 WO disclosed
EP-1385918-A1 SUBSTITUTED FLUORENE POLYMERS, THEIR PREPARATION AND USE IN OPTICAL DEVICES Cambridge Display Technology Limited (GB) 2004-02-04 EP disclosed
WO-2002092723-A1 SUBSTITUTED FLUORENE POLYMERS, THEIR PREPARATION AND USE IN OPTICAL DEVICES CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2002-11-21 WO disclosed