Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3011707 | 0.73 | LTA4H (0.41) | TSHRLTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8044610 | 0.71 | — | — | |
| SCHEMBL25443206 | 0.70 | ALDH1A1 (0.44) | TSHRLMNACYP1A2KMT2AALDH1A1 | |
| SCHEMBL23185729 | 0.70 | ALDH1A1 (0.44) | TSHRLMNACYP1A2KMT2AALDH1A1 | |
| SCHEMBL23177633 | 0.68 | MEN1 (0.39) | TSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL16158023 | 0.68 | GAA (0.39) | TSHRLMNACRBNNPY1RNPY2R | |
| SCHEMBL8084978 | 0.67 | LMNA (0.41) | TSHRLMNACRBNNPY1RNPY2R | |
| SCHEMBL11121933 | 0.67 | TSHR (0.42) | TSHRLTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5403812 | 0.66 | — | — | |
| SCHEMBL4390758 | 0.65 | LTA4H (0.33) | TSHRLTA4HCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058132-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |