Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386824 | 0.87 | HRH3 (0.36) | HRH4HRH3 | |
| SCHEMBL4383625 | 0.82 | HRH3 (0.39) | HRH4HRH3 | |
| SCHEMBL4385039 | 0.79 | TRPV1 (0.36) | HRH3 | |
| SCHEMBL4382422 | 0.79 | TRPV1 (0.36) | HRH3 | |
| SCHEMBL7994725 | 0.76 | L3MBTL1 (0.33) | HRH3CYP2D6CYP2C19 | |
| SCHEMBL439550 | 0.74 | HIF1A (0.35) | HRH3 | |
| SCHEMBL8934768 | 0.74 | — | — | |
| SCHEMBL4381442 | 0.73 | PLA2G2C (0.37) | HRH4HRH3 | |
| SCHEMBL13734799 | 0.73 | MAPT (0.33) | — | |
| SCHEMBL4390122 | 0.72 | HRH3 (0.63) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |