Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385039 | 1.00 | TRPV1 (0.36) | TRPV1HRH3HPGDSMN1; SMN2MAPK1 | |
| SCHEMBL7994725 | 0.94 | L3MBTL1 (0.33) | HRH3HPGDSMN1; SMN2KMT2A | |
| SCHEMBL13734799 | 0.87 | MAPT (0.33) | HPGDSMN1; SMN2KMT2A | |
| SCHEMBL11107449 | 0.85 | TRPV1 (0.33) | TRPV1HRH3 | |
| SCHEMBL11109555 | 0.84 | HRH3 (0.31) | TRPV1HRH3 | |
| SCHEMBL4386824 | 0.82 | HRH3 (0.36) | HRH3 | |
| SCHEMBL11110534 | 0.81 | HRH4 (0.44) | HRH3 | |
| Anisole SCHEMBL18991293 | 0.80 | PTPN1 (0.43) | HRH3SMN1; SMN2KMT2A | |
| SCHEMBL11036952 | 0.79 | HRH2 (0.30) | HRH3 | |
| SCHEMBL4390126 | 0.79 | HRH4 (0.36) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |