Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | ACR | P10323 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071112 | 0.91 | MAPK1 (0.53) | KMT2AKDM4AMAPK1RAB9ANPC1 | |
| SCHEMBL4391261 | 0.86 | MAPK1 (0.52) | KMT2AKDM4AMAPK1RAB9ANPC1 | |
| SCHEMBL22353263 | 0.81 | SLC6A3 (0.58) | KMT2AKDM4ASLC6A3MAPTMEN1 | |
| SCHEMBL1543301 | 0.81 | MAPT (0.41) | KMT2AMAPK1RAB9ANPC1KDM4E | |
| SCHEMBL29597637 | 0.77 | MAPK1 (0.54) | KMT2AMAPK1RAB9ANPC1KDM4E | |
| SCHEMBL29596848 | 0.76 | MAPK1 (0.51) | KMT2ASLC6A3MAPK1RAB9ANPC1 | |
| SCHEMBL5934287 | 0.76 | MAPK1 (0.51) | KMT2ASLC6A3MAPK1RAB9ANPC1 | |
| SCHEMBL1543130 | 0.75 | MAPK1 (0.48) | KMT2AMAPK1RAB9ANPC1KDM4E | |
| SCHEMBL2070250 | 0.75 | TGFBR1 (0.49) | KMT2AMAPK1RAB9ANPC1KDM4E | |
| SCHEMBL3226202 | 0.75 | KDM4A (0.52) | KMT2AKDM4AMAPK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129660-A2 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | Pfizer Products Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008075172-A2 | NICOTINAMIDE DERIVATIVES AS INHIBITORS OF H-PGDS AND THEIR USE FOR TREATING PROSTAGLANDIN D2 MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | disclosed |