SCHEMBL4392301

SCHEMBL4392301

C=CCC(c1nc2cc(-c3ncccn3)ccc2[nH]1)c1nc2cc(-c3ncccn3)ccc2[nH]1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
LMNA P02545 2/20 0.35
HSD17B10 Q99714 1/20 0.35
PIK3CD O00329 1/20 0.33
PIP5K1C O60331 1/20 0.33
PI4KA P42356 1/20 0.33
PIK3CG P48736 1/20 0.33
PI4KB Q9UBF8 1/20 0.33
IDO1 P14902 1/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
AAK1 Q2M2I8 5/20 0.31
KMT2A Q03164 2/20 0.30
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5311131 0.89 KDM4E (0.34) KDM4ELMNAHSD17B10PIK3CDPIP5K1C
SCHEMBL3830827 0.85 KDM4E (0.36) KDM4ELMNAHSD17B10PIK3CDPIP5K1C
SCHEMBL3833275 0.83 KDM4E (0.40) KDM4ELMNAHSD17B10PIK3CDPIP5K1C
SCHEMBL5409668 0.82 KDM4E (0.34) KDM4ELMNAHSD17B10IDO1AAK1
SCHEMBL3837147 0.81 NISCH (0.37) KDM4EIDO1ALDH1A1AAK1
SCHEMBL3835038 0.81 KDM4E (0.38) KDM4ELMNAHSD17B10PIK3CDPIP5K1C
SCHEMBL4392245 0.79 ALDH1A1 (0.40) KDM4ELMNAHSD17B10IDO1ALDH1A1
SCHEMBL3830935 0.78 KDM4E (0.46) KDM4ELMNAHSD17B10PIK3CDPIP5K1C
SCHEMBL3830605 0.78 KDM4E (0.39) KDM4ELMNAHSD17B10AAK1KMT2A
SCHEMBL3835605 0.75 KDM4E (0.38) KDM4ELMNAHSD17B10PIK3CDPIP5K1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1545544-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS Combinatorx, Incorporated (US) 2005-06-29 EP claimed
WO-2004006842-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO claimed
WO-2004006849-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO claimed
EP-2121700-A1 SUBSTITUTED TETRAHYDROQUINOLINES Merck Patent GmbH (DE) 2009-11-25 EP disclosed
EP-2121684-A1 SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES Merck Patent GmbH (DE) 2009-11-25 EP disclosed
WO-2008113452-A1 SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES MERCK PATENT GMBH (DE) 2008-09-25 WO disclosed
WO-2008113451-A1 SUBSTITUTED TETRAHYDROQUINOLINES MERCK PATENT GMBH (DE) 2008-09-25 WO disclosed
EP-1891076-A1 SUBSTITUTED TETRAHYDROQUINOLINES Merck Patent GmbH (DE) 2008-02-27 EP disclosed
EP-1891011-A1 TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 Merck Patent GmbH (DE) 2008-02-27 EP disclosed
EP-1891013-A1 TETRAHYDROQUINOLINE DERIVATIVES Merck Patent GmbH (DE) 2008-02-27 EP disclosed
EP-1885702-A2 QUINAZOLINONES Merck Patent GmbH (DE) 2008-02-13 EP disclosed
WO-2006097176-A1 PHTHALAZINONES MERCK PATENT GMBH (DE) 2006-09-21 WO disclosed
WO-2006094602-A1 INDANE MERCK PATENT GMBH (DE) 2006-09-14 WO disclosed
EP-1651211-A2 COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS Combinatorx, Incorporated (US) 2006-05-03 EP disclosed
WO-2006002726-A1 TETRAHYDROQUINOLINES MERCK PATENT GMBH (DE) 2006-01-12 WO disclosed
WO-2005108355-A2 DIHYDROBENZOTHIOPHENES MERCK PATENT GMBH (DE) 2005-11-17 WO disclosed
WO-2005063735-A1 2-(HETERO)-ARYL-SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2005-07-14 WO disclosed
WO-2005020913-A2 FORMULATIONS, CONJUGATES, AND COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2005-03-10 WO disclosed
WO-2005011572-A2 COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2005-02-10 WO disclosed
WO-2004006849-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO disclosed