Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | F9 | P00740 | 3/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | LIPC | P11150 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.31 |
| ▸ | PRCP | P42785 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833275 | 0.83 | KDM4E (0.40) | KDM4ELMNAHSD17B10MLKLKMT2A | |
| SCHEMBL3830827 | 0.82 | KDM4E (0.36) | KDM4ELMNAHSD17B10MLKLKMT2A | |
| SCHEMBL4392301 | 0.82 | KDM4E (0.35) | KDM4ELMNAHSD17B10SMN1; SMN2MLKL | |
| SCHEMBL3835038 | 0.81 | KDM4E (0.38) | KDM4ELMNAHSD17B10SMN1; SMN2MLKL | |
| SCHEMBL4392245 | 0.79 | ALDH1A1 (0.40) | KDM4ELMNAHSD17B10SMN1; SMN2IDO1 | |
| SCHEMBL3830605 | 0.78 | KDM4E (0.39) | KDM4ELMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL5311131 | 0.76 | KDM4E (0.34) | KDM4ELMNAHSD17B10IDO1AAK1 | |
| SCHEMBL3830935 | 0.76 | KDM4E (0.46) | KDM4ELMNAHSD17B10MLKLIDO1 | |
| SCHEMBL3833347 | 0.76 | AAK1 (0.35) | KDM4ELMNAHSD17B10MLKLKMT2A | |
| SCHEMBL3835605 | 0.73 | KDM4E (0.38) | KDM4ELMNAHSD17B10SMN1; SMN2MLKL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |