SCHEMBL439243

SCHEMBL439243

C[C@]1(n2cnc3c(N)ncnc32)C[C@H](O)[C@@H](CO)O1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 2/20 0.56
ADORA3 P0DMS8 6/20 0.54
ADORA2A P29274 5/20 0.54
PI4KA P42356 4/20 0.51
PI4K2B Q8TCG2 4/20 0.51
PI4K2A Q9BTU6 4/20 0.51
PI4KB Q9UBF8 4/20 0.51
GMPS P49915 1/20 0.48
DPP4 P27487 1/20 0.48
MEN1 O00255 1/20 0.48
MAP3K7 O43318 1/20 0.48
SLC28A2 O43868 1/20 0.48
GAPDH P04406 1/20 0.48
MAPK1 P28482 1/20 0.48
ADORA2B P29275 1/20 0.48
ADORA1 P30542 1/20 0.48
STAT6 P42226 1/20 0.48
KMT2A Q03164 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
DOT1L Q8TEK3 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29799646 1.00 SLC28A1 (0.56) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL444963 0.87 SLC28A1 (0.42) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL29362292 0.85 SLC28A1 (0.57) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL6756465 0.85 SLC28A1 (0.57) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL2335292 0.85 SLC28A1 (0.57) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL9956204 0.85 SLC28A1 (0.57) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL25222252 0.84 SLC28A1 (0.54) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL29786250 0.84 SLC28A1 (0.54) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL3466617 0.84 SLC28A1 (0.56) SLC28A1ADORA3ADORA2API4KAPI4K2B
SCHEMBL66047 0.84 SLC28A1 (0.56) SLC28A1ADORA3ADORA2API4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115943307-A MR1 ligands and pharmaceutical compositions for immunomodulation 巴塞尔大学 2023-04-07 CN claimed
US-20230099822-A1 MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION UNIVERSITÄT BASEL (CH) 2023-03-30 US claimed
CN-114076805-B Method for enriching methylated adenosine in urine and application thereof 浙江大学 2022-07-26 CN claimed
CN-114076805-A Method for enriching methylated adenosine in urine and application thereof 浙江大学 2022-02-22 CN claimed
WO-2021144475-A1 MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION UNIVERSITÄT BASEL (CH) 2021-07-22 WO claimed
EP-4372090-A2 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING GRNAS Editas Medicine, Inc. (US) 2024-05-22 EP disclosed
EP-3215617-B1 SYSTEMS FOR IMPROVING CRISPR/CAS-MEDIATED GENOME-EDITING EDITAS MEDICINE INC (US) 2024-05-08 EP disclosed
EP-4359527-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES Novartis AG (CH) 2024-05-01 EP disclosed
US-20240132877-A1 GENOME EDITING SYSTEMS COMPRISING REPAIR-MODULATING ENZYME MOLECULES AND METHODS OF THEIR USE EDITAS MEDICINE, INC. 2024-04-25 US disclosed
US-20240110179-A1 SYSTEMS AND METHODS FOR TREATING ALPHA 1-ANTITRYPSIN (A1AT) DEFICIENCY EDITAS MEDICINE, INC. (US) 2024-04-04 US disclosed
US-20240067992-A1 HUMAN HEMATOPOIETIC STEM CELL HAVING A MODIFIED BCL11A GENE AND METHODS OF MAKING THE CELL EDITAS MEDICINE, INC. (US) 2024-02-29 US disclosed
US-11911415-B2 CRISPR/Cas-related methods and compositions for improving transplantation EDITAS MEDICINE, INC. (US) 2024-02-27 US disclosed
WO-2010062404-A2 N-FMOC NUCLEOSIDES AND PHOSPHORAMIDITES, AND OLIGONUCLEOTIDE SYNTHESIS CHEMGENES CORPORATION (US) 2010-06-03 WO disclosed
WO-2010027512-A9 RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END CHEMGENES CORPORATION (US) 2010-04-22 WO disclosed
WO-2010027512-A2 RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END CHEMGENES CORPORATION (US) 2010-03-11 WO disclosed
WO-2009115694-A1 METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2009-09-24 WO disclosed
WO-2004058252-A2 ANTI-CANCER AGENTS COMPRISING ALKB INHIBITORS AND ALKYLATING AGENTS ISIS INNOVATION LIMITED (GB) 2004-07-15 WO disclosed
EP-1042348-A4 PLATELET DERIVED GROWTH FACTOR (PDGF) NUCLEIC ACID LIGAND COMPLEXES NEXSTAR PHARMACEUTICALS INC (US) 2004-07-07 EP disclosed
EP-1042348-A1 PLATELET DERIVED GROWTH FACTOR (PDGF) NUCLEIC ACID LIGAND COMPLEXES NeXstar Pharmaceuticals, Inc. (US) 2000-10-11 EP disclosed
WO-1999031119-A1 PLATELET DERIVED GROWTH FACTOR (PDGF) NUCLEIC ACID LIGAND COMPLEXES NEXSTAR PHARMACEUTICALS, INC. (US) 1999-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11911415-B2 CRISPR/Cas-related methods and compositions for improving transplantation HLA-C, HLA-DRB1, HLA-B SLC28A1 1852/4885ADORA3 3662/4885ADORA2A 2375/4885
US-20240067992-A1 HUMAN HEMATOPOIETIC STEM CELL HAVING A MODIFIED BCL11A GENE AND METHODS OF MAKING THE CELL MCL1, BCL2L11, BCL2L13 SLC28A1 2740/4885ADORA3 3683/4885ADORA2A 2447/4885
US-20230099822-A1 MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION MRGPRX1, MRGPRX2, CD47 SLC28A1 772/4885ADORA3 77/4885ADORA2A 82/4885
US-20240132877-A1 GENOME EDITING SYSTEMS COMPRISING REPAIR-MODULATING ENZYME MOLECULES AND METHODS OF THEIR USE DCLRE1B, MPG, UNG SLC28A1 4259/4885ADORA3 3421/4885ADORA2A 2944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.