Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392472 | 1.00 | NPC1 (0.43) | NPC1RAB9ARENHDAC3HDAC4 | |
| SCHEMBL3944730 | 0.96 | NPC1 (0.43) | NPC1RAB9ARENHDAC3HDAC4 | |
| SCHEMBL7048995 | 0.84 | NPC1 (0.48) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL7048992 | 0.84 | NPC1 (0.48) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL13681826 | 0.83 | NPC1 (0.47) | NPC1RAB9ACA1CA2CA9 | |
| SCHEMBL3859822 | 0.83 | NPC1 (0.47) | NPC1RAB9ACA1CA2CA9 | |
| SCHEMBL130361 | 0.82 | BIRC2 (0.47) | NPC1RAB9A | |
| SCHEMBL131149 | 0.82 | BIRC2 (0.47) | NPC1RAB9A | |
| SCHEMBL16898303 | 0.81 | NPC1 (0.50) | NPC1RAB9A | |
| SCHEMBL16898305 | 0.81 | NPC1 (0.50) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203631-A1 | PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBIOTICS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-08-13 | — | — | US | disclosed |
| US-7538085-B2 | Macrocyclic peptide antibiotics; drug resistant, drug sensitive bacterial infections | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-05-26 | — | — | US | disclosed |
| US-20070259812-A1 | Peptide deformylase inhibitors as novel antibiotics | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION | 2007-11-08 | — | — | US | disclosed |
| US-7208595-B2 | Peptide deformylase inhibitors as novel antibiotics | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-04-24 | — | — | US | disclosed |
| US-20050026821-A1 | Peptide deformylase inhibitors as novel antibiotics | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203631-A1 | PEPTIDE DEFORMYLASE INHIBITORS AS NOVEL ANTIBIOTICS | PDF, PADI3, PADI6 | NPC1 3258/4885RAB9A 1699/4885REN 3052/4885 |
| US-20070259812-A1 | Peptide deformylase inhibitors as novel antibiotics | PDF, PADI3, PADI6 | NPC1 3258/4885RAB9A 1699/4885REN 3052/4885 |
| US-20050026821-A1 | Peptide deformylase inhibitors as novel antibiotics | PDF, PADI3, PADI6 | NPC1 3258/4885RAB9A 1699/4885REN 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.