Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10276093 | 0.92 | RAB9A (0.41) | RAB9ANPC1CSF1RPIM1PIM2 | |
| SCHEMBL3787431 | 0.88 | CYP2D6 (0.37) | KMT2AMEN1RAB9ANPC1CSF1R | |
| SCHEMBL10275931 | 0.84 | HRH3 (0.44) | PIK3CAPIK3CB | |
| SCHEMBL3782027 | 0.84 | LGMN (0.35) | KMT2AMEN1RAB9ANPC1CSF1R | |
| SCHEMBL10276136 | 0.83 | HRH3 (0.38) | RAB9ANPC1TSHRPIK3CAPIK3CB | |
| SCHEMBL10276385 | 0.82 | PIK3CD (0.47) | PIK3CAPIK3CB | |
| SCHEMBL3778364 | 0.81 | SMN1; SMN2 (0.38) | RAB9ANPC1TSHRPIK3CAPIK3R1 | |
| SCHEMBL4554726 | 0.81 | SMN1; SMN2 (0.38) | RAB9ANPC1TSHRPIK3CAPIK3R1 | |
| SCHEMBL14955228 | 0.80 | PIK3CA (0.41) | PIK3CAPIK3CBPIK3R1SMN1; SMN2 | |
| SCHEMBL3809370 | 0.80 | HRH3 (0.37) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-A2 | PHARMACEUTICAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007127175-A2 | PHARMACEUTICAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-08 | — | — | WO | disclosed |