Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778364 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTRAB9AKDM4ECYP1A2 | |
| SCHEMBL10276093 | 0.86 | RAB9A (0.41) | SMN1; SMN2MAPTRAB9AKDM4EPIK3CA | |
| SCHEMBL1860764 | 0.84 | NCF1 (0.45) | SMN1; SMN2MAPTRAB9AKDM4ECYP1A2 | |
| SCHEMBL10276136 | 0.82 | HRH3 (0.38) | SMN1; SMN2MAPTRAB9AKDM4EPIK3CA | |
| SCHEMBL4392568 | 0.81 | KMT2A (0.36) | SMN1; SMN2MAPTRAB9APIK3CAPIK3R1 | |
| SCHEMBL14954840 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTRAB9AKDM4ECYP1A2 | |
| SCHEMBL10275931 | 0.79 | HRH3 (0.44) | PIK3CAMTOR | |
| SCHEMBL3782027 | 0.79 | LGMN (0.35) | SMN1; SMN2MAPTRAB9AKDM4ECYP1A2 | |
| SCHEMBL4566067 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTRAB9AKDM4ECYP1A2 | |
| SCHEMBL4564507 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTRAB9AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |