Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033347 | 0.85 | CD44 (0.36) | CYP3A4ALDH1A1TSHRPIK3CA | |
| SCHEMBL5460684 | 0.77 | CD44 (0.39) | CYP3A4TDP1TSHRPIK3CA | |
| SCHEMBL18403717 | 0.75 | ALDH1A1 (0.43) | CYP3A4TDP1ALDH1A1ALOX15CASP1 | |
| SCHEMBL1922650 | 0.75 | KDM4E (0.33) | CYP3A4TDP1ALDH1A1TSHR | |
| SCHEMBL5465268 | 0.75 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL5462581 | 0.75 | IDO1 (0.32) | TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL5465608 | 0.75 | NOS3 (0.40) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL5584654 | 0.74 | CYP3A4 (0.39) | CYP3A4TDP1ALDH1A1ALOX15CASP1 | |
| SCHEMBL2082921 | 0.73 | LMNA (0.40) | TDP1ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL1431415 | 0.72 | CYP3A4 (0.33) | CYP3A4TSHRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252144-B1 | SUBSTITUTED GLUTARIMIDES AND USE THEREOF IL-12 PRODUCTION INHIBITORS | GRUENENTHAL GMBH (DE) | 2009-12-09 | — | — | EP | disclosed |
| EP-1252144-A1 | SUBSTITUTED GLUTARIMIDES AND USE THEREOF IL-12 PRODUCTION INHIBITORS | Grünenthal GmbH (DE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001053261-A1 | SUBSTITUTED GLUTARIMIDES AND USE THEREOF IL-12 PRODUCTION INHIBITORS | Grünenthal GmbH (DE) | 2001-07-26 | — | — | WO | disclosed |