Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395139 | 1.00 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL6976561 | 0.91 | NOS1 (0.42) | NOS3NOS1NOS2 | |
| SCHEMBL6976565 | 0.91 | NOS1 (0.42) | NOS3NOS1NOS2 | |
| SCHEMBL4478117 | 0.82 | ADRB3 (0.40) | — | |
| SCHEMBL4398421 | 0.79 | NOS3 (0.60) | NOS3NOS1NOS2 | |
| SCHEMBL4398437 | 0.79 | NOS3 (0.40) | NOS3NOS1NOS2 | |
| SCHEMBL4398439 | 0.79 | NOS3 (0.40) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL4393258 | 0.78 | NOS3 (0.59) | NOS3NOS1NOS2 | |
| SCHEMBL4400155 | 0.77 | KCNH2 (0.57) | — | |
| SCHEMBL4399979 | 0.77 | NOS1 (0.54) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576241-B2 | Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them | IPSEN PHARMA S.A.S. (FR) | 2009-08-18 | — | — | US | disclosed |
| US-20060084667-A1 | New derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them | IPSEN PHARMA S.A.S. (FR) | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084667-A1 | New derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them | ADM2, NUP155, ABCG2 | NOS3 100/4885NOS1 247/4885NOS2 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.