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Leucine

Leucine

SCHEMBL4395800

CC(C)C[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 1/20 0.36
▸ REN P00797 2/20 0.36
▸ SLC1A3 P43003 1/20 0.31
▸ SLC1A2 P43004 1/20 0.31
▸ DPP4 P27487 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoleucine SCHEMBL10428546 0.92 NOS2 (0.35) RENDPP4
Leucine SCHEMBL4397081 0.92 SLC7A5 (0.43) SLC7A5RENSLC1A3SLC1A2DPP4
Leucine SCHEMBL4391463 0.92 SLC7A5 (0.43) SLC7A5RENSLC1A3SLC1A2DPP4
Leucine SCHEMBL4398129 0.92 SLC7A5 (0.43) SLC7A5RENSLC1A3SLC1A2DPP4
Isoleucine SCHEMBL10428545 0.92 NOS2 (0.35) RENDPP4
Isoleucine SCHEMBL25386165 0.92 NOS2 (0.35) RENDPP4
Leucine SCHEMBL27509633 0.91 SLC7A5 (0.37) SLC7A5RENSLC1A3SLC1A2DPP4
Leucine SCHEMBL27468590 0.91 SLC7A5 (0.44) SLC7A5RENSLC1A3SLC1A2DPP4
Leucine SCHEMBL18249977 0.91 SLC7A5 (0.44) SLC7A5RENSLC1A3SLC1A2DPP4
Leucine SCHEMBL5957028 0.90 SLC7A5 (0.36) SLC7A5RENSLC1A3SLC1A2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11384117-B2 Connective tissue stimulating peptides OCTANE ORTHOBIOLOGICS INC. (CA) 2022-07-12 — — US disclosed
US-20190077831-A1 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2019-03-14 — — US disclosed
US-10202419-B2 Connective tissue stimulating peptides OCTANE ORTHOBIOLOGICS INC. (CA) 2019-02-12 — — US disclosed
US-20160237117-A1 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2016-08-18 — — US disclosed
US-9133236-B2 Connective tissue stimulating peptides MILLENIUM BIOLOGIX INC. (CA) 2015-09-15 — — US disclosed
US-20120156276-A1 Connective tissue stimulating peptides MILLENIUM BIOLOGIX INC. (CA) 2012-06-21 — — US disclosed
US-7491691-B2 Connective tissue stimulating peptides OCTANE ORTHOBIOLOGICS INC. (CA) 2009-02-17 — — US disclosed
US-20050288229-A1 Connective Tissue Stimulating Peptides MILLENIUM BIOLOGIX INC. (CA) 2005-12-29 — — US disclosed
EP-1504033-A2 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2005-02-09 — — EP disclosed
WO-2003093314-A2 CONNECTIVE TISSUE STIMULATING PEPTIDES MILLENIUM BIOLOGIX INC. (CA) 2003-11-13 — — WO disclosed