Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 12/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.33 |
| ▸ | FAP | Q12884 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL10428545 | 1.00 | NOS2 (0.35) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL25386165 | 1.00 | NOS2 (0.35) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL28801805 | 0.96 | REN (0.33) | NOS2NOS3NOS1DPP4DPP8 | |
| Leucine SCHEMBL4395800 | 0.92 | SLC7A5 (0.36) | DPP4REN | |
| Isoleucine SCHEMBL138093 | 0.90 | DPP4 (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL1537461 | 0.90 | DPP4 (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL1537322 | 0.90 | DPP4 (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL1537321 | 0.90 | DPP4 (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL703839 | 0.90 | DPP4 (0.40) | NOS2NOS3NOS1DPP4DPP8 | |
| Isoleucine SCHEMBL1537458 | 0.90 | DPP4 (0.40) | NOS2NOS3NOS1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | claimed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | claimed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | disclosed |