Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 8/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 8/20 | 0.46 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | KDM5C | P41229 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 3/20 | 0.40 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 9/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729136 | 0.88 | — | — | |
| Oxalic Acid SCHEMBL4382975 | 0.86 | ALDH1A1 (0.36) | PHF8KDM2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL728781 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL27282182 | 0.83 | ALDH1A1 (0.37) | ALDH1A1 | |
| Dimethylamine SCHEMBL8787992 | 0.81 | PHF8 (0.56) | PHF8KDM2AKDM7AEGLN1KDM5C | |
| Glutamic Acid SCHEMBL4392480 | 0.80 | GRM8 (0.58) | FOLH1 | |
| Fumaric Acid SCHEMBL4390032 | 0.80 | TSHR (0.39) | EGLN1ALDH1A1 | |
| Fumaric Acid SCHEMBL4390034 | 0.80 | TSHR (0.39) | EGLN1ALDH1A1 | |
| Sulfuric Acid SCHEMBL4395779 | 0.79 | ALDH1A1 (0.34) | ALDH1A1 | |
| Phosphoric Acid SCHEMBL4387115 | 0.79 | ALDH1A1 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123251-B1 | COMPOSITION FOR EXTERNAL APPLICATION TO SKIN | SHISEIDO CO LTD (JP) | 2014-09-17 | — | — | EP | disclosed |
| EP-2123251-A1 | COMPOSITION FOR EXTERNAL APPLICATION TO SKIN | Shiseido Company, Limited (JP) | 2009-11-25 | — | — | EP | disclosed |