Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4390032 | 1.00 | TSHR (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL729136 | 0.86 | — | — | |
| Oxalic Acid SCHEMBL4382975 | 0.84 | ALDH1A1 (0.36) | ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL728781 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL27282182 | 0.81 | ALDH1A1 (0.37) | TSHRALDH1A1GAA | |
| Succinic Acid SCHEMBL4397250 | 0.80 | PHF8 (0.46) | EGLN1ALDH1A1 | |
| SCHEMBL4369066 | 0.79 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Sulfuric Acid SCHEMBL4395779 | 0.77 | ALDH1A1 (0.34) | ALDH1A1GAA | |
| Phosphoric Acid SCHEMBL4387115 | 0.77 | ALDH1A1 (0.34) | ALDH1A1GAATDP1 | |
| Trifluoroacetic Acid SCHEMBL4846623 | 0.77 | CACNA1B (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123251-B1 | COMPOSITION FOR EXTERNAL APPLICATION TO SKIN | SHISEIDO CO LTD (JP) | 2014-09-17 | — | — | EP | disclosed |
| EP-2123251-A1 | COMPOSITION FOR EXTERNAL APPLICATION TO SKIN | Shiseido Company, Limited (JP) | 2009-11-25 | — | — | EP | disclosed |