Dimethylamine

Dimethylamine

SCHEMBL8787992

CN(C)C(=O)CCC(=O)O.CNC

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PHF8 Q9UPP1 8/20 0.56
KDM2A Q9Y2K7 8/20 0.56
KDM7A Q6ZMT4 2/20 0.48
ALDH1A1 P00352 1/20 0.46
EGLN1 Q9GZT9 5/20 0.45
LMNA P02545 2/20 0.45
ALKBH5 Q6P6C2 1/20 0.45
SUCNR1 Q9BXA5 1/20 0.45
KDM5C P41229 4/20 0.44
KDM4E B2RXH2 3/20 0.44
KDM6B O15054 3/20 0.43
KDM4A O75164 6/20 0.42
KDM4C Q9H3R0 6/20 0.42
SLC15A2 Q16348 1/20 0.42
CHRNB2 P17787 1/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA4 P43681 1/20 0.39
FOLH1 Q04609 1/20 0.39
KDM5A P29375 1/20 0.38
FFAR3 O14843 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL322794 0.92 PHF8 (0.64) PHF8KDM2AKDM7AALDH1A1EGLN1
Hydrochloric Acid SCHEMBL1375668 0.90 PHF8 (0.61) PHF8KDM2AKDM7AALDH1A1EGLN1
Succinic Acid SCHEMBL4397250 0.81 PHF8 (0.46) PHF8KDM2AKDM7AALDH1A1EGLN1
SCHEMBL1191256 0.81 ALDH1A1 (0.63) PHF8KDM2AALDH1A1LMNAKDM4A
Succinic Acid SCHEMBL5875196 0.81 EGLN1 (0.69) PHF8KDM2AKDM7AEGLN1LMNA
Succinic Acid SCHEMBL5875205 0.81 EGLN1 (0.69) PHF8KDM2AKDM7AEGLN1LMNA
SCHEMBL10897803 0.78 PHF8 (0.54) PHF8KDM2AKDM7AEGLN1LMNA
Succinic Acid SCHEMBL9472424 0.78 EGLN1 (0.64) PHF8KDM2AKDM7AEGLN1LMNA
SCHEMBL812501 0.77 ALDH1A1 (0.61) ALDH1A1LMNACHRNB2CHRNB4CHRNA4
SCHEMBL6688889 0.77 ALDH1A1 (0.61) PHF8KDM2AALDH1A1LMNACHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0681580-B1 PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES PFIZER (US) 1997-07-09 EP disclosed
EP-0681580-A1 PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES. PFIZER HOSPITAL PROD (US) 1995-11-15 EP disclosed
WO-1994017061-A1 PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES PFIZER INC. (US) 1994-08-04 WO disclosed
US-5270331-A Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides PFIZER, INC. (US) 1993-12-14 US disclosed
US-4117531-A VALVE METAL ELECTRODES, AMMONIUM OR AMINE SALT OF MALEAMIC, SUCCINAMIC, PHTHALAMIC, OR HEXAHYDROPHTHALAMIC ACID IN DIMETHYLFORMAMIDE, N-METHYLFORMAMIDE, GLYCOL, OR GLYCOL-METHYLCELLOSOLVE SPRAGUE ELECTRIC COMPANY (US) 1978-09-26 US disclosed