Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL4397340

COc1ccc(CNCCc2cccc(Br)c2)cc1.N

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.60
BCHE P06276 4/20 0.60
MEN1 O00255 3/20 0.60
ATM Q13315 1/20 0.59
HTR2A P28223 2/20 0.55
GAA P10253 1/20 0.55
ALDH1A1 P00352 3/20 0.54
TAAR1 Q96RJ0 1/20 0.53
KDM4E B2RXH2 2/20 0.52
NPC1 O15118 1/20 0.52
CHRM2 P08172 1/20 0.51
CA12 O43570 1/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA4 P22748 1/20 0.51
CA9 Q16790 1/20 0.51
GPBAR1 Q8TDU6 1/20 0.51
HTT P42858 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10032816 0.81 MEN1 (0.85) KMT2ABCHEMEN1ATMGAA
SCHEMBL12131075 0.81 MEN1 (0.85) KMT2ABCHEMEN1ATMGAA
SCHEMBL3243773 0.79 TAAR1 (0.54) KMT2ABCHEMEN1GAATAAR1
SCHEMBL29194688 0.78 BCHE (0.80) KMT2ABCHEMEN1ATMHTR2A
SCHEMBL8496610 0.78 BCHE (0.79) KMT2ABCHEMEN1ATMHTR2A
SCHEMBL4103249 0.77 KDM4E (0.74) KMT2AMEN1ATMHTR2AGAA
SCHEMBL2580897 0.76 LTA4H (0.63) KMT2AMEN1ALDH1A1TAAR1
SCHEMBL29880536 0.76 LTA4H (0.63) KMT2AMEN1ALDH1A1TAAR1
SCHEMBL19524534 0.76 GAA (0.63) KMT2ABCHEMEN1GAATAAR1
SCHEMBL21089609 0.75 TAAR1 (0.60) KMT2AMEN1GAAALDH1A1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7553809-B2 Fc receptor modulators and uses thereof ILEXUS PTY LIMITED (AU) 2009-06-30 US disclosed
US-20060057144-A1 Fc receptor modulators and uses thereof ILEXUS PTY LIMITED (AU) 2006-03-16 US disclosed
US-6835753-B2 Administering to the patient for inhibiting Fc receptor binding of immunoglobulin a compound selected from aromatic, heteroaromatic, cyclic, bicyclic and an amino acid derivative or salt ILEXUS PTY LIMITED (AU) 2004-12-28 US disclosed
US-20020061844-A1 Administering to the patient for inhibiting Fc receptor binding of immunoglobulin a compound selected from aromatic, heteroaromatic, cyclic, bicyclic and an amino acid derivative or salt ILEXUS PTY LIMITED 2002-05-23 US disclosed
US-6355683-B1 ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE ILEXUS PTY LIMITED (AU) 2002-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020061844-A1 Administering to the patient for inhibiting Fc receptor binding of immunoglobulin a compound selected from aromatic, heteroaromatic, cyclic, bicyclic and an amino acid derivative or salt FCGR2A, FCGR1A, FCER2 KMT2A 2002/4885BCHE 2250/4885MEN1 4070/4885
US-20060057144-A1 Fc receptor modulators and uses thereof FCGR1A, FCER2, FCGR2A KMT2A 3334/4885BCHE 1586/4885MEN1 3751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.