Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16977977 | 1.00 | NAMPT (0.45) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL15799018 | 0.85 | NAMPT (0.41) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL17259176 | 0.85 | NAMPT (0.41) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL15799019 | 0.85 | NAMPT (0.41) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL15805103 | 0.85 | NAMPT (0.41) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3881829 | 0.84 | IDO1 (0.40) | IDO1CHRNA7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL440450 | 0.83 | FFAR1 (0.53) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL30455741 | 0.83 | NAMPT (0.44) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL16977978 | 0.83 | FFAR1 (0.53) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL18518580 | 0.83 | FFAR1 (0.53) | NAMPTCYP3A4ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617251-B2 | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-04-11 | — | — | US | disclosed |
| US-20170037040-A1 | INDANYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-09 | — | — | US | disclosed |
| US-9029381-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-05-12 | — | — | US | disclosed |
| US-20120065193-A1 | Cyclopropyl Amide Derivatives '978 | ASTRAZENECA AB (SE) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037040-A1 | INDANYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | GPR119, GPR55, GPR65 | NAMPT 1943/4885CYP3A4 1142/4885ALDH1A1 1240/4885 |
| US-20120065193-A1 | Cyclopropyl Amide Derivatives '978 | HRH2, HRH4, HRH3 | NAMPT 1633/4885CYP3A4 1713/4885ALDH1A1 1104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.