Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TPSAB1 | Q15661 | 13/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4401837 | 0.99 | CYP3A4 (0.54) | CYP3A4CYP2D6KCNH2TPSAB1 | |
| Hydrochloric Acid SCHEMBL4408025 | 0.94 | CYP3A4 (0.55) | CYP3A4CYP2D6KCNH2TPSAB1 | |
| SCHEMBL4399220 | 0.84 | TPSAB1 (0.62) | TPSAB1 | |
| Hydrochloric Acid SCHEMBL4408182 | 0.83 | TPSAB1 (0.61) | TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL6324575 | 0.78 | TPSAB1 (0.57) | CYP3A4CYP2D6KCNH2TPSAB1 | |
| Hydrochloric Acid SCHEMBL4396161 | 0.78 | TPSAB1 (0.62) | TPSAB1 | |
| Hydrochloric Acid SCHEMBL4404473 | 0.77 | TPSAB1 (0.54) | CYP3A4CYP2D6KCNH2TPSAB1 | |
| SCHEMBL8350361 | 0.77 | TPSAB1 (0.58) | TPSAB1 | |
| SCHEMBL13830735 | 0.75 | TPSAB1 (0.60) | CYP3A4CYP2D6KCNH2TPSAB1 | |
| SCHEMBL15788480 | 0.75 | TPSAB1 (0.52) | CYP3A4CYP2D6KCNH2TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-B1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMA INC (US) | 2009-12-23 | — | — | EP | claimed |
| US-6977263-B2 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-20 | — | — | US | claimed |
| US-20050228018-A1 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-13 | — | — | US | claimed |
| US-20030187020-A1 | Chemical compounds | AVENTISUB LLC | 2003-10-02 | — | — | US | claimed |
| EP-1296972-B1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMA INC (US) | 2009-12-23 | — | — | EP | disclosed |
| US-6977263-B2 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-20050228018-A1 | Chemical compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-13 | — | — | US | disclosed |
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228018-A1 | Chemical compounds | CMA1, TPSB2, TPSG1 | CYP3A4 1205/4885CYP2D6 1526/4885KCNH2 2745/4885 |
| US-20030187020-A1 | Chemical compounds | CMA1, TPSB2, TPSG1 | CYP3A4 1205/4885CYP2D6 1526/4885KCNH2 2745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.