Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 5/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399131 | 1.00 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL8225007 | 0.90 | MAPT (0.52) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL6062430 | 0.88 | CA12 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL6062427 | 0.88 | CA12 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9457600 | 0.88 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9457593 | 0.88 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL2711160 | 0.88 | CA12 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL2726872 | 0.84 | CTSS (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL2726873 | 0.84 | CTSS (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL2726870 | 0.84 | CTSS (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511039-B2 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | MYRIAD GENETICS, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20060293372-A1 | Beta-sheet mimetics and methods relating to the use thereof | MYRIAD GENETICS, INC. (US) | 2006-12-28 | — | — | US | disclosed |
| US-20060276408-A1 | Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | MYRIAD GENETICS, INCORPORATED (US) | 2006-12-07 | — | — | US | disclosed |
| US-7125872-B2 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | MYRIAD GENETICS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1661566-A2 | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors | MYRIAD GENETICS, INC. (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-0915700-B1 | USE OF BETA-SHEET MIMETICS AS PROTEASE AND KINASE INHIBITORS AND AS INHIBITORS OF TRANSCRIPTION FACTORS | MYRIAD GENETICS INC (US) | 2006-03-22 | — | — | EP | disclosed |
| US-20040230035-A1 | Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | MYRIAD GENETICS, INC. (US) | 2004-11-18 | — | — | US | disclosed |
| US-6699869-B1 | PROTEASE INHIBITORS, ANTICOAGULANT | MYRIAD GENETICS INC. | 2004-03-02 | — | — | US | disclosed |
| US-20030191109-A1 | Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | KAHN MICHAEL (US) | 2003-10-09 | — | — | US | disclosed |
| US-6586426-B1 | Pyrrolizine derivatives; thrombin, elastase, and factor X inhibitors | MOLECUMETICS LTD. | 2003-07-01 | — | — | US | disclosed |
| EP-1053246-B1 | BETA-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF | MOLECUMETICS LTD (US) | 2003-01-02 | — | — | EP | disclosed |
| US-6372744-B1 | PROTEASE OR KINASE INHIBITORS | MOLECUMETICS LTD. | 2002-04-16 | — | — | US | disclosed |
| EP-0815123-B1 | BETA-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS | MOLECUMETICS LTD (US) | 2001-10-04 | — | — | EP | disclosed |
| US-6245764-B1 | PROTEASE INHIBITORS; ANTICANCER AGENTS; IMMUNOLOGY CONTROLLERS; ANTIINFLAMMATORY AGENTS | MOLECUMETICS LTD. | 2001-06-12 | — | — | US | disclosed |
| US-6117896-A | Methods for regulating transcription factors | MOLECUMETICS LTD. (US) | 2000-09-12 | — | — | US | disclosed |
| US-6020331-A | β-sheet mimetics and use thereof as protease inhibitors | MOLECUMETICS, LTD. (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0817642-A1 | $g(b)-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS | MOLECUMETICS, LTD. (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0815123-A1 | $g(b)-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS | MOLECUMETICS, LTD. (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996030396-A1 | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS | MOLECUMETICS LTD. (US) | 1996-10-03 | — | — | WO | disclosed |
| WO-1996030035-A1 | β-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS | MOLECUMETICS LTD. (US) | 1996-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293372-A1 | Beta-sheet mimetics and methods relating to the use thereof | SERBP1, PACSIN2, HGFAC | ALDH1A1 4694/4885CYP3A4 4684/4885CYP2C9 4880/4885 |
| US-20030191109-A1 | Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | MICA, BMX, CD74 | ALDH1A1 4307/4885CYP3A4 4834/4885CYP2C9 4680/4885 |
| US-20060276408-A1 | Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | SERPINB1, SERPINE1, SERPINA2 | ALDH1A1 4098/4885CYP3A4 4231/4885CYP2C9 4515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.