Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 3/20 | 0.41 |
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857637 | 0.87 | EDNRA (0.53) | KMT2AKDM4EEDNRBEDNRAALDH1A1 | |
| SCHEMBL7593404 | 0.80 | KMT2A (0.55) | KMT2ALMNASMN1; SMN2KDM4EGAA | |
| SCHEMBL28662112 | 0.78 | MEN1 (0.43) | KMT2ASMN1; SMN2KDM4EPOLBFOLH1 | |
| SCHEMBL7134859 | 0.77 | KMT2A (0.44) | KMT2ALMNASMN1; SMN2KDM4ERCE1 | |
| SCHEMBL11791604 | 0.77 | KMT2A (0.62) | KMT2ALMNASMN1; SMN2KDM4EAGTR1 | |
| SCHEMBL7607181 | 0.76 | KMT2A (0.43) | KMT2ALMNASMN1; SMN2KDM4ERCE1 | |
| SCHEMBL6017853 | 0.71 | SMN1; SMN2 (0.53) | KMT2ALMNASMN1; SMN2KDM4EGAA | |
| SCHEMBL16144912 | 0.71 | LMNA (0.53) | KMT2ALMNASMN1; SMN2KDM4EGAA | |
| SCHEMBL29625463 | 0.70 | GPR3 (0.52) | KMT2ALMNAKDM4EPOLBALDH1A1 | |
| SCHEMBL2608424 | 0.70 | GPR3 (0.52) | KMT2ALMNAKDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081894-A1 | 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS | SmithKline Beecham Corporation (US) | 2009-07-29 | — | — | EP | claimed |
| WO-2008028118-A1 | 1H-INDOLE-2-CARBOXYLIC ACID DERIVATIVES USEFUL AS PPAR MODULATORS | SMITHKLINE BEECHAM CORPORAITON (US) | 2008-03-06 | — | — | WO | claimed |