Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421429 | 0.79 | CCR2 (0.51) | KMT2AEDNRASMN1; SMN2LMNAKDM4E | |
| SCHEMBL7593404 | 0.79 | KMT2A (0.55) | KMT2ASMN1; SMN2LMNAKDM4EPOLB | |
| SCHEMBL28665614 | 0.77 | MEN1 (0.44) | KMT2ASMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL4399199 | 0.76 | KMT2A (0.48) | KMT2AEDNRASMN1; SMN2LMNAKDM4E | |
| SCHEMBL7134859 | 0.76 | KMT2A (0.44) | KMT2AEDNRASMN1; SMN2LMNAKDM4E | |
| SCHEMBL11791604 | 0.76 | KMT2A (0.62) | KMT2AEDNRASMN1; SMN2LMNAKDM4E | |
| SCHEMBL27673202 | 0.75 | MCL1 (0.48) | KMT2AKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL4712636 | 0.73 | MAPK8 (0.53) | MAPK8TACR1ACLY | |
| SCHEMBL6857637 | 0.72 | EDNRA (0.53) | KMT2AEDNRAKDM4EEDNRBALDH1A1 | |
| SCHEMBL16144912 | 0.70 | LMNA (0.53) | KMT2ASMN1; SMN2LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165517-A1 | N-BENZIMIDAZOLYLMETHYL- AND N-INDOLYLMETHYL-BENZAMIDES AND THEIR USE AS CRF MODULATORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6281237-B1 | MODULATORS OF CRF RECEPTORS AND ARE THEREFORE USEFUL FOR TREATING AFFECTIVE DISORDERS, ANXIETY, DEPRESSION, EATING DISORDERS, AND STRESS DISORDERS | NEUROGEN CORPORATION | 2001-08-28 | — | — | US | disclosed |
| WO-2000059888-A1 | N-BENZIMIDAZOLYLMETHYL- AND N-INDOLYLMETHYL-BENZAMIDES AND THEIR USE AS CRF MODULATORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |