Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 7/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SOD3 | P08294 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369682 | 0.87 | GNAO1 (0.43) | SIGMAR1GNAO1GNAI3GNAI1SOD3 | |
| SCHEMBL21581280 | 0.85 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1SLC6A2 | |
| SCHEMBL18761564 | 0.85 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1SLC6A2 | |
| SCHEMBL22702328 | 0.85 | GNAO1 (0.42) | SIGMAR1GNAO1GNAI3GNAI1SOD3 | |
| SCHEMBL18612783 | 0.85 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1SLC6A2 | |
| SCHEMBL22019451 | 0.85 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1SLC6A2 | |
| SCHEMBL28210517 | 0.85 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1SLC6A2 | |
| SCHEMBL21581261 | 0.85 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1SLC6A2 | |
| SCHEMBL674946 | 0.85 | CXCR4 (0.46) | SIGMAR1SMN1; SMN2SLC6A2SLC6A4CXCR4 | |
| SCHEMBL22702329 | 0.84 | SIGMAR1 (0.42) | SIGMAR1GNAO1GNAI3GNAI1SOD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319274-A1 | Identification of Compounds Modifying a Cellular Response | CARLSBERG A/S (DK) | 2011-12-29 | — | — | US | disclosed |
| EP-1761783-B1 | IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE | 2CUREX APS (DK) | 2009-07-29 | — | — | EP | disclosed |
| EP-1761783-A2 | IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE | Carlsberg A/S (DK) | 2007-03-14 | — | — | EP | disclosed |
| WO-2007009457-A2 | IDENTIFICATION OF PROTEIN LIGANDS MODIFYING A CELLULAR RESPONSE | 2CUREX APS (DK) | 2007-01-25 | — | — | WO | disclosed |
| WO-2005116643-A2 | IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE | CARLSBERG A/S (DK) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319274-A1 | Identification of Compounds Modifying a Cellular Response | MYD88, CD14, STAT1 | SIGMAR1 2802/4885GNAO1 1678/4885GNAI3 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.