SCHEMBL4399655

SCHEMBL4399655

NCCCC[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ OPRL1 P41146 4/20 0.54
▸ TFPI P10646 1/20 0.49
▸ OPRM1 P35372 3/20 0.48
▸ OPRD1 P41143 3/20 0.48
▸ KISS1R Q969F8 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4399651 1.00 OPRL1 (0.54) OPRL1TFPIOPRM1OPRD1KISS1R
SCHEMBL31243859 0.89 OPRD1 (0.58) OPRL1TFPIOPRM1OPRD1
SCHEMBL31243865 0.89 OPRD1 (0.58) OPRL1TFPIOPRM1OPRD1
SCHEMBL31480024 0.89 OPRL1 (0.63) OPRL1TFPIOPRM1OPRD1
SCHEMBL29408578 0.89 ERAP2 (0.53) —
SCHEMBL29575653 0.87 TFPI (0.57) OPRL1TFPI
SCHEMBL13811868 0.87 TFPI (0.60) OPRL1TFPIKISS1R
SCHEMBL31243908 0.86 OPRD1 (0.55) OPRL1TFPIOPRM1OPRD1
SCHEMBL10747004 0.86 OPRL1 (0.59) OPRL1TFPI
SCHEMBL10746970 0.86 OPRL1 (0.59) OPRL1TFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7553809-B2 Fc receptor modulators and uses thereof ILEXUS PTY LIMITED (AU) 2009-06-30 — — US disclosed
US-20060057144-A1 Fc receptor modulators and uses thereof ILEXUS PTY LIMITED (AU) 2006-03-16 — — US disclosed
CN-1189166-C FC receptor modulators and uses thereof ILEXUS PTY LTD (AU) 2005-02-16 — — CN disclosed
US-6835753-B2 Administering to the patient for inhibiting Fc receptor binding of immunoglobulin a compound selected from aromatic, heteroaromatic, cyclic, bicyclic and an amino acid derivative or salt ILEXUS PTY LIMITED (AU) 2004-12-28 — — US disclosed
US-20020061844-A1 Administering to the patient for inhibiting Fc receptor binding of immunoglobulin a compound selected from aromatic, heteroaromatic, cyclic, bicyclic and an amino acid derivative or salt ILEXUS PTY LIMITED 2002-05-23 — — US disclosed
US-6355683-B1 ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE ILEXUS PTY LIMITED (AU) 2002-03-12 — — US disclosed
CN-1323203-A FC receptor modulators and uses thereof ILEXUS PTY LTD (AU) 2001-11-21 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020061844-A1 Administering to the patient for inhibiting Fc receptor binding of immunoglobulin a compound selected from aromatic, heteroaromatic, cyclic, bicyclic and an amino acid derivative or salt FCGR2A, FCGR1A, FCER2 OPRL1 211/4885TFPI 1232/4885OPRM1 1097/4885
US-20060057144-A1 Fc receptor modulators and uses thereof FCGR1A, FCER2, FCGR2A OPRL1 318/4885TFPI 348/4885OPRM1 1093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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