Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880 | 0.85 | METAP2 (0.37) | METAP2MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3730 | 0.83 | MEN1 (0.44) | METAP2MEN1KMT2ARAB9AL3MBTL1 | |
| Oxalic Acid SCHEMBL4399 | 0.77 | KDM4E (0.49) | METAP2MEN1KMT2APPARGPPARA | |
| SCHEMBL5078661 | 0.76 | HTR1B (0.48) | METAP2MEN1KMT2ASLC6A2SLC6A4 | |
| Formic Acid SCHEMBL3879 | 0.75 | HTR1B (0.42) | METAP2MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3924 | 0.74 | SLC6A4 (0.56) | MEN1KMT2ARAB9AOPRM1MAPT | |
| Oxalic Acid SCHEMBL3729 | 0.73 | KMT2A (0.54) | MEN1KMT2AOPRM1SLC6A2SLC6A4 | |
| Oxalic Acid SCHEMBL27413669 | 0.73 | KMT2A (0.49) | METAP2MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3312531 | 0.72 | SLC6A2 (0.56) | MEN1KMT2ARAB9AOPRM1ALDH1A1 | |
| SCHEMBL2741 | 0.72 | SLC6A2 (0.56) | MEN1KMT2ARAB9AOPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |