Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.42 |
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5078661 | 0.93 | HTR1B (0.48) | KDM4EMEN1KMT2AHTR1BMETAP2 | |
| Formic Acid SCHEMBL3879 | 0.91 | HTR1B (0.42) | KDM4EMEN1KMT2AALDH1A1HTR1B | |
| Oxalic Acid SCHEMBL3729 | 0.85 | KMT2A (0.54) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| Oxalic Acid SCHEMBL27413669 | 0.80 | KMT2A (0.49) | KDM4EMEN1KMT2AALDH1A1METAP2 | |
| SCHEMBL4400 | 0.77 | METAP2 (0.41) | MEN1KMT2AALDH1A1METAP2SLC6A2 | |
| SCHEMBL27445526 | 0.76 | SLC6A4 (0.49) | KDM4EMEN1KMT2AHTR1BSLC6A2 | |
| SCHEMBL3730 | 0.73 | MEN1 (0.44) | MEN1KMT2AALDH1A1METAP2SLC6A2 | |
| SCHEMBL3880 | 0.73 | METAP2 (0.37) | KDM4EMEN1KMT2AALDH1A1HTR1B | |
| Oxalic Acid SCHEMBL3923 | 0.72 | SLC6A4 (0.61) | KDM4EMEN1KMT2AALDH1A1HTR1B | |
| Oxalic Acid SCHEMBL4054 | 0.72 | SLC6A4 (0.50) | KDM4EMEN1KMT2ASLC6A4UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |