Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.66 |
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | PLD2 | O14939 | 5/20 | 0.57 |
| ▸ | PLD1 | Q13393 | 5/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399511 | 0.91 | CHRM1 (0.66) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL4403836 | 0.87 | DRD2 (0.72) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL3002989 | 0.82 | CHRM1 (0.66) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL4444715 | 0.82 | CHRM1 (0.69) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL8891261 | 0.81 | CHRM1 (0.67) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL2997304 | 0.80 | CHRM1 (0.61) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL9974821 | 0.79 | OPRM1 (0.61) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL4565235 | 0.78 | DRD2 (0.52) | CHRM1DRD2OPRM1CYP2D6CYP2C9 | |
| SCHEMBL22298693 | 0.78 | OPRM1 (0.67) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL14593699 | 0.78 | OPRM1 (0.60) | CHRM1DRD2OPRM1PLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035412-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | Astra Zeneca AB (SE) | 2009-03-18 | — | — | EP | claimed |
| WO-2007142585-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | claimed |
| EP-2035412-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | Astra Zeneca AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007142585-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |