Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.69 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.69 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.69 |
| ▸ | DRD2 | P14416 | 3/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.65 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.65 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | PLD2 | O14939 | 2/20 | 0.54 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443440 | 0.90 | OPRM1 (0.80) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL8891261 | 0.89 | CHRM1 (0.67) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL9974821 | 0.85 | OPRM1 (0.61) | CHRM1DRD2OPRM1SIRT2PLD2 | |
| SCHEMBL1152842 | 0.84 | CHRM1 (0.61) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL4444487 | 0.84 | CHRM1 (0.72) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL14593699 | 0.83 | OPRM1 (0.60) | CHRM1DRD2OPRM1PLD2PLD1 | |
| SCHEMBL6577844 | 0.82 | HSD11B1 (0.62) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL11594238 | 0.82 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL4919819 | 0.82 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM3DRD2 | |
| SCHEMBL4572894 | 0.82 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124883-A1 | NOVEL 1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009124883-A1 | NOVEL 1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-10-15 | — | — | WO | disclosed |