Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.77 |
| ▸ | ARG2 | P78540 | 4/20 | 0.48 |
| ▸ | ARG1 | P05089 | 3/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 6/20 | 0.43 |
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28229793 | 1.00 | GSR (0.77) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL29244083 | 1.00 | GSR (0.77) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL26606338 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28697152 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28193353 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28185340 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL50314 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL27006 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL273455 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL28241453 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118286495-A | Fast-curing adhesive, and preparation method and application thereof | 诺一迈尔(山东)医学科技有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-117897424-A | Aqueous polyurethane urea dispersions | 科思创德国股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-115569244-B | Sandwich type degradable biological material and application thereof | 珠海睿展生物材料有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117551414-A | Adhesive composition, preparation method and application thereof | 科思创德国股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-114763403-B | Low-color TMP type polyisocyanate composition and preparation method thereof | 万华化学集团股份有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-117229700-A | Two-component coating composition | 科思创德国股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-116802774-A | Hollow microsphere | 株式会社德山 | 2023-09-22 | — | — | CN | disclosed |
| CN-112105676-B | Low water content polyrotaxane monomer and curable composition containing the same | 株式会社德山 | 2023-08-29 | — | — | CN | disclosed |
| US-11685805-B2 | Aqueous dispersion of polyurethane | COVESTRO DEUTSCHLAND AG (DE) | 2023-06-27 | — | — | US | disclosed |
| CN-116096771-A | Adhesive composition, preparation method and application thereof | 科思创德国股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-112079989-A | Aqueous polyurethane dispersions | 科思创德国股份有限公司 | 2020-12-15 | — | — | CN | disclosed |
| CN-111333803-A | Optical resin composition, optical resin material and application thereof | 万华化学集团股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-110959020-A | Compositions, their preparation and their use | 科思创德国股份有限公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-110857329-A | Polyurethane composition and preparation method and application thereof | 科思创德国股份有限公司 | 2020-03-03 | — | — | CN | disclosed |
| CN-110857385-A | Composition and preparation method and application thereof | 科思创德国股份有限公司 | 2020-03-03 | — | — | CN | disclosed |
| CN-110607120-A | Coating composition | 科思创德国股份有限公司 | 2019-12-24 | — | — | CN | disclosed |
| EP-3555161-A1 | AN AQUEOUS DISPERSION OF POLYURETHANE | Covestro Deutschland AG (DE) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018114838-A1 | AN AQUEOUS DISPERSION OF POLYURETHANE | COVESTRO DEUTSCHLAND AG (DE) | 2018-06-28 | — | — | WO | disclosed |
| US-20090130174-A1 | POLY (ESTER URETHANE) UREA FOAMS WITH ENHANCED MECHANICAL AND BIOLOGICAL PROPERTIES | VANDERBILT UNIVERSITY | 2009-05-21 | — | — | US | disclosed |
| WO-2009026387-A1 | POLY(ESTER URETHANE) UREA FOAMS WITH ENHANCED MECHANICAL AND BIOLOGICAL PROPERTIES | VANDERBILT UNIVERSITY (US) | 2009-02-26 | — | — | WO | disclosed |